The impacts upon the growth space station of several advanced planetary missions and a populated lunar base are examined. Planetary missions examined include sample returns from Mars, the Comet Kopff, the main belt asteroid Ceres, a Mercury orbiter, and a saturn orbiter with multiple Titan probes. A manned lunar base build-up scenario is defined, encompassing preliminary lunar surveys, ten years of construction, and establishment of a permanent 18 person facility with the capability to produce oxygen propellant. The spacecraft mass departing from the space station, mission Delta V requirements, and scheduled departure date for each payload outbound from low Earth orbit are determined for both the planetary missions and for the lunar base build-up. Large aerobraked orbital transfer vehicles (OTV's) are used. Two 42 metric ton propellant capacity OTV's are required for each the the 68 lunar sorties of the base build-up scenario. The two most difficult planetary missions (Kopff and Ceres) also require two of these OTV's. An expendable lunar lander and ascent stage and a reusable lunar lander which uses lunar produced oxygen are sized to deliver 18 metric tons to the lunar surface. For the lunar base, the Space Station must hangar at least two non-pressurized OTV's, store 100 metric tons of cryogens, and support an average of 14 OTV launch, return, and refurbishment cycles per year. Planetary sample return missions require a dedicated quarantine module.